Use of BAL in the Treatment of Arsenical Neuropathy
نویسنده
چکیده
BAL 01* British Anti-Lewisite which is 2, 3 dimercaptopropanol was evolved in Professor Peters' Laboratory at Oxford by Peters, Stocken and Thompson in 1945, as an effective antidote to Lewisite. It has since been used successfully in several forms of metallic poisoning including arsenic, mercury and other heavy metals. Eagle and Magnuson (1946) found it efficacious in 5 cases of arsenical encephalopathy. Holley (1947) reported on the successful treatment of 12 cases of agranulocytosis due to arsenic. Armstrong and his co-workers found this agent to be effective in mapharside overdosage. Schrumpf (1947) and Friedenberg (1947) found this agent useful in blood dyscrasias and optic neuritis due to arsenic. Longcope and Luetscher (1949) have summarized the published literature on the uses of BAL in the treatment of the injurious effects of heavy metals and in arsenical dermatitis.
منابع مشابه
Clinical Uses of 2,3-dimercaptopropanol (bal). Vii. the Treatment of Arsenical Dermatitis with Preparations of Bal.
The development of 2,3-dimercaptopropanol (British Anti-Lewisite, BAL) by Peters, Stocken, and Thompson (1) has made available a potent antidote for arsenical poisoning. Study of the chemical combination of arsenic with sensitive enzymes and cells indicated that the arsenic could, under certain circumstances, be removed from the cells, and that enzymes could be reactivated by the action of BAL ...
متن کاملClinical Uses of 2,3-dimercaptopropanol (bal). Ii. the Effect of Bal on the Excretion of Arsenic in Normal Subjects and after Minimal Exposure to Arsenical Smoke.
متن کامل
Clinical uses of 2,3-dimercaptopropanol (BAL); the effect of BAL on the excretion of arsenic in arsenical intoxication.
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Effects of enalapril on diabetic neuropathy in rats
Background: Neuropathy is one of the important complications of diabetes. Deficiency of the nerve conduction velocity (NCV) that occurs in both human diabetic neuropathy and animal diabetes models is one of the indicators for diabetic neuropathy. In the present study, we examined the effect of enalapril, angiotensinconverting enzyme inhibitor on NCV, number of endoneurial capillaries and th...
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عنوان ژورنال:
دوره 86 شماره
صفحات -
تاریخ انتشار 1951