Use of BAL in the Treatment of Arsenical Neuropathy

نویسنده

  • S. L. Malhotra
چکیده

BAL 01* British Anti-Lewisite which is 2, 3 dimercaptopropanol was evolved in Professor Peters' Laboratory at Oxford by Peters, Stocken and Thompson in 1945, as an effective antidote to Lewisite. It has since been used successfully in several forms of metallic poisoning including arsenic, mercury and other heavy metals. Eagle and Magnuson (1946) found it efficacious in 5 cases of arsenical encephalopathy. Holley (1947) reported on the successful treatment of 12 cases of agranulocytosis due to arsenic. Armstrong and his co-workers found this agent to be effective in mapharside overdosage. Schrumpf (1947) and Friedenberg (1947) found this agent useful in blood dyscrasias and optic neuritis due to arsenic. Longcope and Luetscher (1949) have summarized the published literature on the uses of BAL in the treatment of the injurious effects of heavy metals and in arsenical dermatitis.

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منابع مشابه

Clinical Uses of 2,3-dimercaptopropanol (bal). Vii. the Treatment of Arsenical Dermatitis with Preparations of Bal.

The development of 2,3-dimercaptopropanol (British Anti-Lewisite, BAL) by Peters, Stocken, and Thompson (1) has made available a potent antidote for arsenical poisoning. Study of the chemical combination of arsenic with sensitive enzymes and cells indicated that the arsenic could, under certain circumstances, be removed from the cells, and that enzymes could be reactivated by the action of BAL ...

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عنوان ژورنال:

دوره 86  شماره 

صفحات  -

تاریخ انتشار 1951